Since the launch of the Amazon DRM free mp3 store, the way I shop for music has changed. I still prefer to browse for my music using iTunes. When I find something I want to buy I head over to Amazon.com mp3 store to see if its available in a higher quality DRM free version. If it is available it's usually at a cheaper price than iTunes.
Apparently this is how others do it also. I did a short post about this on Twitter and @PhillyMac_Chat sent me a link to a wonderful free script that makes this whole process easier.